i use the win 296 and the 300gr xtps for handgun hunting here in Ohio,21.6 gr,wlpp.starline brass,out of my 7.5 inch blackhawk im pushing over 1250 fps and have taken whitetails out to 100, although most shots are at 75 yrds or less up here we have thick woods,i have caught them crossing feilds and power cuts and slammed em with a 300 grainer,i set for 80 yrd zero gives me dead on at 100 as well,i wont take a shot over 100 most times.Being as Ohio has the idiotic shotgun only law, i use my pistol, that slug gun beats heck out of me i can shoot my blackhawk all day and never get a flinch.Hogs in sth fla have been victims of my blackhawk 45. i shot more than a few when i lived in sth fla.Off the back of an airboat most times ,drt.never took a step.Along with a few big gators.