Igor,

I've used my .44 and .50 Desert Eagles (with either 2x Leupolds or red dots) to harvest multiple white-tailed deer. The .44 shoots 4-6" @ 100yds with the old Speer 270gr. Gold Dots and will do 2-4" at 100 yds. with my handloads and a steady rest. I wouldn't hesitate to use them on something bigger than deer, I just haven't had the opportunity yet. I've had 4 Desert Eagle barrels in various lengths and all have been more accurate than I am capable of shooting offhand so that has really been the limiting factor.