284,

Lots of good information provided for your here. Here is my two cents.

I have had good results with the 158 grain FP-XTP behind the shoulder. I like a 180 or so grain WFN cast better. It can take out the shoulders (a shot which I personally like) and my experience with the several deer I have shot with this bullet has been bang-flop. The cast bullet will also get the job done behind the shoulder. I shot a big bodied buck last year through-and-through the lungs because it was the only shot opportunity I had. The exit hole was half-dollar size. Not the best blood trail (which can be a knock on this type of bullet) for the first 30 yards but he only ran 40 yards. The blood pressure is going to drop precipitously with gaping holes in the lungs.

So, I personally like the heavy cast bullet, because I firmly believe it gives me more options to take an ethical shot.

I am glad the hunting fires are still burning and I hope the Python strikes this year.