Sir you are ready to go in my opinion. I'm not sure what your velocity is but I guess its >1250 fps should kill a deer like a hammer. It is obvious that you are proficient with the Ruger.

BTW I am a ridiculous tinkerer also, but the first time I shot my 45 colt with 13gr of HS6 I saw no need to tinker. I feel like I can kill anything in North America (well it can). It's accurate and recoils little. There are much more powerful loads but "can I shoot them as well?".