I have owned and used (and killed big game) with both the.475 Linebaugh and the .500 Wyoming Express calibers (that is a Freedom Arms round which gives up little to the .500 L, (maybe a few thousandths in diameter and a few hundred FPS).

I killed a nice mule deer buck as well as a doe antelope (not extensive experience, I freely admit) with the .500 WE in a FA Model 83 revolver; both were one shot kills with complete pass throughs. I also killed two mature bull elk in Colorado (a nice 5X5 and a great 5X6) with the .475 L in a custom built revolver by Rod.

Again, full complete pass throughs but not extensive experience.

But again, from my limited experience, as well as what I have read, I prefer the .475 if I only could have one.

Not for any "real" reason; but just because I am giving you my opinion here.
Most would agree that both create large enough holes without bullet expansion and have plenty of penetration power, so both will fill the bill.

Actually I believe that I heard from someone on here that the .475 is the leader of the two in penetration tests.

Gregg