I get 1,400 with a 250 in my 45 Colt and find that sufficient for my purposes. More speed will net a flatter trajectory, deeper penetration and a more significant wound channel but MN deer and bear don't really warrant it at the distances I usually hunt. That said, I am building a Striker that will push a 45 caliber 250 grain slug in excess of 2,200 fps. Why? Who knows ;-)