Larry one of the advantages I see is the ability to buy ammo such as the 185 +P ammo and head for the woods. I have shot two deer with 185grs out of a .45 Super and it killed them just fine. I don't have any illusions about any auto cartridge less than a .50AE going toe to toe with my 360gr loads from my .45 wheelgun. I think that the semi autos may be the Rodney Dangerfield of the handgun hunting world.

"A quiet hit in the right place is better than a loud miss in the wrong place followed by 10 more shots on the run"

I was a handgun hunter, when handgun wasn't cool.....