My "thumper load" in a 4" barrel, 24.0 gr of W296, Fed 155 mag primer, 300 gr LFNGC (Bear Tooth Bullets) clocks 1,100 fps with a spread of 27 fps.
For everyday carry on the ranch I load 10 grs of Unique with same bullet at 950 fps. This covers everything I'll come up against here in western Washington State, no grizzly's here.
For practice; 300 gr cast FP from Oregon Trail w/ 7 grs of Tight Group for 830 fps.
Also FYI, a really good thumper in .45 colt is from Buffalo Bore, with their 325 gr LFNGC, out of my 4" I get 1,230 fps.! Use sparingly in that N frame.