I use all different calibers, scopes, red dots and iron sights. I love hunting any big game I get the opportunity to hunt. I use Ruger's, Freedom Arms' and a custom. Bullets vary by brand, type and weight.
All that being said, the whitetail deer is the big game I hunt the most; for the obvious reason. Although I like and use all, my most prefered for whitetail is a scoped Freedom Arms revolver with mid-weight for caliber jacketed bullets and my shots are generally under 75 yards due to my hunting methods.