I use both. My all around woods gun is a S&W 629 with 2x B&L scope. Load is 240 XTP over max charge of H-110. I will go iron sights if the cover is heavy or when walking / still hunting in thick cover. I always carry an iron sighted revolver cross draw when I am hunting with a scoped gun. Either a Redhawk 44 mag or a Super Blackhawk 44 Mag. The same load as above. I also have a heavy 300 XTP load for the Redhawk if the game is bigger than deer.
In general the above comments pertain to Whitetail deer and black bear hunting although it would also apply to feral hogs. For larger game or in the open land where the shots are 100 yards or more I would opt for a scoped Contender with the 44 on my belt.