Absolutely! The Foster 20 gauge slug is softer than a good hard cast bullet in a 500 Linebaugh, but similar weight and velocity, 382 gr at 1450 fps. The sabot rounds are a better choice, Hornady 20 ga 2 3/4" 300 grain SST at 1800 fps (probably long barrel so expect less) uses the same bullet they load in the 500 S&W Mag.