Going into grizzly country, I carry my 4 inch 45 Colt Redhawk with Buffalo Bore 325 P+ rounds in it. Back here in PA, I use a Taurus 450 Titanium with Buffalo Bore 255 SWC Heavy Standard Pressure loads... it would be a good round for the model 25. I know there are recipes for handloading either one.

I definitely would not try "Ruger Only" loads in a model 25.