I prefer single actions.
I currently have a ruger bisley in 44 mag.
I also prefer open sights However and 55 my eyes are not what they were.
I may down the road go to a reflex dot sight.
As far as bullets the only game Ive killed is two whitetail.
One with a factory winchester silvertip HP (Impressive blood trail)
The other was a 180 grain XTP (no blood, poor shot placement)

Im looking at cast bullets this year.