I've got the 460 on a TC Encore Pro Hunter with a custom barrel from MGM. I had the XVR Performance Center revolver, but like the Encore platform in this chambering MUCH better. I'm throwing 300 grain XTP MAG's at 1948fps with better than MOA accuracy out of this gun. It is my go to gun for anything out to 200+ yards. Haven't taken any game at that distance yet, but certainly won't hesitate to do it when the chance comes. I am looking at Africa next year as well, and this gun will be going with me without any hesitation.

454 will get it done as well. I've not owned any guns specific for this chambering, but those that do speak very highly of them.

The 460 and the 454 both shoot bullets that are .452" diameter, so I don't think you can go wrong either way. If you do go with the 460, don't shoot the "scam" bullets (200 grains). Use a heavier bullet, and get the full potential out of the gun!