Going by numbers alone, both cartridges are pretty similar in power, and with proper shot placement your quarry will go down just as quickly regardless of which one you choose. I think it would come down to what size gun you'd want to pack around with you, or whether you want to use a revolver or Encore. I have a S&W Model 460 XVR, so I can tell you for a fact it's quite the hefty handgun to carry around.