Iv"e never been to Africa, two thoughts, the 460 gets gets short changed because people use the wrong bullet, I base this on the 200 gr. FTX bullet, this bullet is good, this is my opinion, for deer, and nothing bigger than midsize game, for deer, it"s a great bullet, for bigger game, you got to go to the 300 gr XTP MAG, the 454 was designed for African game, the 454 can shank the biggest game out there, so can the 460, you just have to use the right bullet.