I understand your arguments but, this has been done with success in every pistol caliber available to use more than one size ammo.
It probably isn't as much a problem with the 1/10" gap that other cartridges may have to travel, but when a bullet has to travel over half an inch unsupported in a 460 cylinder, it doesn't help accuracy. Can it be done? Sure! Can you make shorter rounds work? Maybe. Will the 460 rounds be more accurate? Absolutely.
Just because poster is going to Africa, doesn't mean he travel without cleaning equipment?
Not sure what cleaning equipment has to do with an unsupported bullet.
X2. Sorry Steve, but I don't know where you got that I was talking about cleaning the cylinder, which is a different issue altogether.