Plenty of 45 LC data out there.
What you have to be careful is thin wall brass. You can drive a 255 SWC out of a 6 inch barrel at 800 - 850, but kiss the brass goodbye.
Stay away from fast powders and don't sweat the slow pushing powder. Please, no magnum primers.
If your reloading is successful, should be able to down your game within 20 to 40 yards with good placement.
Star Brass once offered 45 LC brass which 1000 fps was easily attainable. Try getting some and throw the old brass away.
If you don't cast/reload, get Ammo Plus. The Blackhawk should handle them all day.