Darrell, That`s interesting about how far your first water buff traveled after taking three rounds from the 450 express rifle compared to the 454.... I remember my first Cape buff took three rounds from my 416 Rigby rifle while the second one dropped at the first shot with my FA`s 500WE. My Florida water buff ( though nowhere near as large as yours ) took a 400gr XTP from my FA`s 475LB and shook like he was electrocuted. I doubt there`s a typical reaction from any of the world`s large buffalo when taken with a handgun or rifle for that matter....