I have custom Smith and Wesson model 16 chambered in this fine cartridge. I shoot a 120 grain cast GC HP loaded over a max dose of WW296 it hits hard and shoots really well. I would not hesitate to use it on deer within 50 yards and if shot opportunity would allow a broadside or angling away. I might add in water soaked news print I got great upset and 16.75" of penetration.