Last year my brother took an average Missouri buck with his Super RedHawk 44 using my cast 310 grain WFN-GC bullets. He hit him high the first shot and he stayed on his feet. He kept shooting and had him on the ground in about 20 feet from the first shot. We recovered 2 of the 310 grain cast bullets expanded nicely to my complete surprise. I would have bet that you could not have have kept one of them in a deer except maby shot end to end. You never quit learning.
While near perfect for deer, my thoughts at the time was for tougher game I would need to harden up the alloy a little more.

Between all of us we collectively have a great deal of experiance on bullets. Some of us probably get away with using bullets that are not perfect due to putting the bullets where they belong in the first place.
This has been a good read, with lots of good points being brought up.

Bob