Colonel Doug Wesson`s big game hunting with the 357 Magnum, if used as a basis of judgement of the handgun as a hunting weapon, leaves nothing to be desired in the way of performance. And as bluecow says above "not many of us would say today that the 357 is medicine for grizzly" or for most of the game Col.Wesson took....
However, he knew his game and where to hit them and had full faith in his weapon of choice and how to shoot it.....Know your gun...know your game....and any limitations that follow.