I do crop damage deer with a .22-250 XP and 40 gr. BTs around houses where I don't want exits. It does really good out to 200, but I pick perfect broadside lung shots.
My all around do everything is a XP and Encore in 6.5/.284 with muzzle break. Mild recoil, almost no muzzle rise, and has proven itself time and time again on deer out to 550 yards with a Burris BPlex scope.