I have a 5 inch muzzle-brake 460 Smith and Wesson Magnum X-frame that will be back from their Performance Center sometime soon. With it, I can shoot hot 45 Colt 360 grain at 1200 fps, or 454 Casull with 360 grain at 1500 fps. And if all else fails, I can use a 395 grain cast bullet from Corbon. I am convinced that this one gun can handle any hunting or large game defensive situation a person could come up with. I like that if one arm gets hurt and unable to be used, I may still be able to shoot it double-action to defend myself.