Today`s hunting handguns and bullets for large game have never been better....
454 Casull - 475 and 500 Linebaugh - 500WE and JRH - 460 and 500S&W...
Add to them a quality, heavy for caliber cast bullet along with the Punch, Barnes solid and hollow points, Swift and a few more, so the only reason for not taking what you want is lack of money to hunt what big game you like or not placing the bullet where it should go on the large animal...This can be an expensive sport..