I read where a .460 shooter loaded/shot/hunted with the 250 XTP for deer and hogs. Has no complaints and DRT animals.
I have used the 250txp in 45 colt, 454 casull and .50 cal muzzleloader with no issues. Even at upper end 454 levels, it performed great. In my opinion, it is the best of the XTP family of bullet. I've read of forcing cone erosion from using in, but I've experienced no such issues; I guess if it does, I deal with it then.