No doubt they can work, no doubt i can post videos of failures on animals as small as corsican rams and follow with good results as well. Its all about how consistent the product is. 100%, 80%, or 50/50? Thats the only knock on em. I believe doc rogers had a statement that if he recovers a bullet on whitetail he wont use em on bigger animals or something to that effect. Obviously worked on those buffs. Itd be interesting to see the bullets pulled out of the animal