My first 2 big game handgun kills back in 1987 were with the 180 gr Sierra 44 mag. I shot 2 antelope does with my Ruger SBH opening morning.

The first shot was at 92 steps (back before I had a range finder) and the doe ran about 60 yards. The second was at 135 steps and that one ran almost 200 yards with a broke shoulder.

Both of these were one shot kills. I had no complaints with that 180 gr bullet