Charles, that should be a very good bullet at 1000 fps but I'm guessing with a good barrel you can exceed that with no problem if the bullets are flat base instead of bevel base.
You'll just have to load some & give them a test drive. The 45 is a superb game killer & does it with modest recoil. I've taken 4 elk with mine. All with iron sights & Keith bullets, except for that calf in the above photo, it was with a 325 gr LBT in my 5 1/2" Bisley.

Dick