The Ruger Redhawk in 45 Colt and 45 ACP with moon clips is a good one. John Taffin wrote up in American Handgunner, or maybe it was Guns magazine, about how the Ruger Redhawk moon clips could be altered to shoot 45 Winchester Magnum, 45 Rowland and other semi-auto 45 caliber iterations. It is a candidate to be all the hunting handgun you will ever need. And then you can have it customized the way you would like it. Power and versatility in a package that is easy to carry in a shoulder holster or crossdraw holster on the hip.
From mild to reasonably wild using Redhawk Only Garrett 405 grain Long Colt loads.