I've bounced back and forth from .44 and .45 caliber cartridges, but I would have to say the O'le .44 Remmy Mag has been my constant. 250 to 300 grain slugs ridding on a stiff charge of IMR 4227 has sent many critters, steel gongs and paper bullseyes on to The Promise Land for me. I can't think of one negative thing to say about the .44 Mag. The runner up for me would go to the .45 Colt. . .and a strong runner up it is!