I agree with more velocity to a point. The venerable 45 Colt does not equal the velocity of the 454 Casull due to a lower pressure threshold. Yet the 45 Colt can be as effective in bringing down what requires killing, loaded to its safe levels with hard cast bullets. With a wide meplat included with its construction.
High pressure increases velocity but that is not the end all consideration. High pressure also increases recoil velocity. Low pressure with big bullets is still effective for penetration. Momentum imparted is key. After the bullet strikes bullet weight and bullet integrity takes over.