Penetration through one animal and into a hill on the other side is wasted and excessive force. Penetration through one animal and into another is excessive also. An example is warranted. On a hunt for Cape Buffalo in Africa, a 45/70 with a heavy cast bullet was used. At the shot the heavy cast bullet penetrated through the target buffalo and continued on to hit another buffalo on the other side. Both succumbed to the injury. That meant that over-penetration occurred, and collateral damage ensued.
If more velocity is always necessary, than why are lower velocity and lower pressure offerings offered by the factory ammunition suppliers like HSM and Federal allowed? Would that not lead to more wounding by doing so? No it does not. The shot is placed, by the odds, more accurately and the lower velocity works well with the bullets selected.
Big bovines deserve deepest penetration and I understand your premise. Just realize that moderation from extremes is a very efficient balance contest that can even apply to the big bovines of the animal kingdom.