U can. Use the faster heavy hitters. Use and buy a couple thousand swift aframes and fire from any angle. If u wanna run light loads ya need a solid. Ive used aframes as small as 210 gr out of a 41 on bison and killed numerous over a 1000 lb animals with aframes at different angle with 454?s and 460?s. Change that to a 480 and a 44 and im using solids on animals that size which, if placed correctly with kill with aplomb. Monometal is better for the really big stuff. Got good penetration and down a cape buff going away from me at 150 yards with a 460 with an aframe