Of all the components that come into play when using a cartridge in a revolver to hunt and kill BIG game, it is the bullet that is most important. Why? Because that is the only vehicle that actually touches the game, and is meant to kill it as humanely as possible.
The integrity of that bullet to do as it was designed to do is of paramount importance. So do proper research before you use a bullet to kill your game. The humane thing is to kill the animal as quickly as possible. Bullet placement and bullet integrity go hand in hand. Keep both at your highest concern and action when hunting.