Chance, The key words that JM say`s are "chose wisely"... I`ve only taken four animals with my S&W 460 and after using the 200gr FTX I would say that on a broadside, double lung shot it can be spectacular, however, angle shots on whitetail can be a disaster. A going away shot on a deer only gave a few inches of penetration with the bullet coming apart (photo below). There are many good hunting bullets that can take advantage of the 460`s velocity making it a deadly hunting handgun. The last critter I took with the 460 was a decent boar at an even 50yds. The ammo was factory 300gr JFP with one broadside shot... The blood spray was impressive.. With the right bullet the 460 can take whatever can be taken...