You ask about multi caliber revolver, correct?

a 41 or 44mag gives you the 41 or 44Spl. In the 480 you would have to go with the 475 in order to shoot the 480 also.
Can't go reverse.

How about a single revolver that can be a do it all?

The 454 is a very good choice since you can also shoot 45 Colt and even if you never reload you can find some very good choices in Factory Fodder. A BFR is a very good choice for the Money.
The BFR in the 460 is a choice that would be very hard to beat, given velocities and bullet choices. Plus you can also shoot 454 and 45 Colt from it.
Both submissions should have the Bisley grip.