With my revolvers, I have a scoped Super Redhawk in .44 Magnum that I have sighted to be dead on at 100 yards. I might stretch is a bit to 125 or so, if I have a rock steady rest. But, for me 100 yards would be my comfortable range. I've taken deer out to 75 yards with this gun.

I have a non-scoped Super Blackhawk also in .44 Magnum but it wears a Burris Fastfire 3 red dot mounted on it. This is my short range handgun and I have it set to be dead on at 50 yards. I have and will stretch this out to 100 yards, again from a nice, solid rest.