I equate hunting with an iron sighted revolver to bow hunting. About 40 to 50 yards would be comfortable for me. At 50 yards the normal front sight covers about 6 inches, and combine that with the fact that most factory guns, with the exception of Freedom Arms, will be lucky to hold a 2 1/2 inch group at that distance. If I mount a red dot sight with a 4 MOA dot, I might be tempted to push that to a hundred yards, but 70 to 80 would be a comfortable limit. If I'm using one of my Freedom Arms with a 4x Leupold or a 2-6X Bushnell, then 100 to 125 becomes comfortable, providing I have a good rest. Revolver/handgun bullets are stubby and drop velocity very quickly, so for me, 125 yards is pretty much max. When I'm shooting sub inch groups at 100 yards with my Contenders, I find it very hard to even consider using a revolver at that distance or beyond.