I've been shooting a FA .454 Casull for several years now. I sight in dead on at 100 yds and have shot a lot of ground hogs out to 160 yards. My hold over at that range is 5-6 inches. I practice out to 200 yds, and drop there is a foot. Hunting big game I'm comfortable out to that 160 yard mark with a good rest. Mostly I've been using crossed sticks and rest my hands on a backpack. Using a Vortex Venom with the 3 moa dot. Load is 300 gr XTP over 31.1 gr H110. The 2 elk I've shot with it have been under 100 yards.