I've had good luck with the Speer Gold Dot 180 grain factory load. First was at 47 yards out of a Colt SAA and the second was out of a FA 97 at 102 yards. On the 102 yard shot, the deer ran 70 yards and bedded, and not wanting to risk losing it, I was able to get to 25 yards below a terrace and put a second in it just to be sure.

PH