Thanks to all for the feedback. I figured I might get mixed results.
I'm sure the 243 is quite capable of killing large game up to 100 yards or more. I was concerned about being able to throw a heavy enough bullet accurately and break bones and/or penetrate deeply out farther without out the shot having to be ultra-precise. Don't get me wrong, I aim small to miss small and only take shots that I have high confidence in. I just don't want to be under-powered at distance.
Thanks to the commenters, I checked the MGM site and there are more options there than T/C offers for the Encore. I think I'll give some of those consideration too.