I've been preaching the Sierra 220 gr. RN in the .300 Whisper for a few decades. Tumbles great, creates decent internal damage, and very accurate out to 300 yds. Works great on deer, groundhogs, turkeys.
The 220 Sierra HPBT does NOT work , at least, in the Whisper. Not quite long enough to tumble. Get pencil tip size holes all the way through a deer. The few I shot with it took 4-5 minutes for them to die. They gave absolutely no reaction to the shot. I thought I missed them.
The 240/250 HPBT, though, performs really good in the Whisper (that's what JD originally used when he developed the Whisper). Jagged exits, little less internal damage than the 220, excellent penetration, and accurate out to 300 yds.
I haven't killed 1000 deer with the Whisper, but the 115 I've done have given me a bunch of experience with this great round.
You .32-20 guys might want to consider Lehigh subsonics. They out perform the 220 & 240 Sierras.