I don't see what gun you plan to load for in 45 Colt, but my experience is with Ruger 7 1/2" large frame revolvers and Contenders. I've loaded for the 250 gr XTP and Deep Curl, and both are very accurate bullets. I know the XTP performs well on deer, but I haven't connected with a DC bullet yet. Some experienced handgun hunters think the DC is a more consistent performer in big game. Both bullets can attain velocities of 1350+ fps with 296 powder from 7 1/2" barrels. Start at 24.0 grs and work up, assuming you are using a full sized Ruger or Contender. The 240 gr XTP is probably a Mag bullet and is designed to perform better at magnum velocities, like out of a 454 Casull. Best of luck to you.