The 44 magnum has always had an edge in penetration.For some it is even more effective than the 454 Casull. Larry Kelly proved the bullet used made the 44 magnum useless in penetration aka jacketed hollow points versus supreme penetration with hardcast heavyweight examples.I would recommend the 325 grain A-frame for your 454 Casull and Africa. As the shot may come from an off angle or not at all and the extra weight could make it doable.