I have taken two coyotes with 44 mag revolvers over the years. They were just targets of opportunity while deer hunting. Both times the bullet was a Hornady 240gr XTP, with the first load being 24.0 grains of AA5744 doing about 1350 fps. The second load is now pretty much my one size fits all using 12.0 grains of Longshot and a Fed 150 primer for a little over 1200 fps out of my 6 1/2 inch S&W 629. Both times were center of shoulder or pretty close, with the result being the coyote slammed to the ground. Both guns were/are scoped, but could have been used for the same effect if they had irons.