I cant imagine a bullet in a 10 mm that is so fragile that it will not handle a deer. i am not a 10 mm shooter but i do shoot a 40 sw and would not hesitate with any reasonable factory loading. the 40 was my duty weapon for 20 years and i shot at least 50 car hit deer from point blank to 75 yards with it and if hit in the goodies they were done with one. most that i could check were pass thru's when i stayed off the shoulder. give them a try on test media and let us know.