Many years ago [sillywet days] I used large rifle primers in a 44 mag Ruger SBH. Actually, they worked quite well. I was using Remington brass that was probably fired more than 5 times. I noticed if I hand primed them they protruded slightly but, if I used the press I could seat them flush. Now, I would not recommend using them and it has to raise pressures. I do not know if the gun was that strong or I was just lucky nothing happened.