Sam, you could say I use a handgun regularly for whitetail hunting. Last one I killed with a rifle was 1977. Since then it's been 100% handguns for whitetails, AK, western hunting and Africa.
I use an enormous # of handguns from 6mm AI to .416 Taylor for whitetails. My #1 gun is a XP in 6.5/.284. Killed over 500 with it out to 500+ yards. Best whitetail bullets seem to be Nosler BTs, Sierra Game Kings. Many others will work, but these seem to be the most consistent- soft, expand well, and accurate.
As of last week my whitetail handgun total is 2512, so you could say I've killed a few.