I lost count of deer I killed with 44 specials using 240-250 grain cast bullets at roughly 1000fps. If you use a jacketed expanding bullet at those velocities and put the bullet where I needs to go you won't get explosive expansion but you will stop what makes them live.

"A quiet hit in the right place is better than a loud miss in the wrong place followed by 10 more shots on the run"

I was a handgun hunter, when handgun wasn't cool.....